Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 63:829-834 (2008)
© 2008 The Gerontological Society of America

SPECIAL ARTICLE

Sarcopenia != Dynapenia

Brian C. Clark and Todd M. Manini

1 Interdisciplinary Institute for Neuromusculoskeletal Research, Department of Biomedical Sciences, Ohio University College of Osteopathic Medicine, Athens.
2 Department of Aging and Geriatric Research, Institute on Aging, University of Florida College of Medicine, Gainesville.

Address correspondence to Brian Clark, PhD, Department of Biomedical Sciences, Ohio University, 211 Irvine Hall, Athens, OH 45701. E-mail: clarkb2{at}ohio.edu or Todd Manini, PhD, Department of Aging & Geriatric Research, University of Florida, P.O. Box 112610, Gainesville, FL 32611. E-mail: tmanini{at}aging.ufl.edu

Abstract

Maximal voluntary force (strength) production declines with age and contributes to physical dependence and mortality. Consequently, a great deal of research has focused on identifying strategies to maintain muscle mass during the aging process and elucidating key molecular pathways of atrophy, with the rationale that the loss of strength is primarily a direct result of the age-associated declines in mass (sarcopenia). However, recent evidence questions this relationship and in this Green Banana article we argue the role of sarcopenia in mediating the age-associated loss of strength (which we will coin as dynapenia) does not deserve the attention it has attracted in both the scientific literature and popular press. Rather, we propose that alternative mechanisms underlie dynapenia (i.e., alterations in contractile properties or neurologic function), and urge that greater attention be paid to these variables in determining their role in dynapenia.

Key Words: Aging • Strength • Atrophy • Sarcopenia • Dynapenia






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