Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Salmon, A. B.
Right arrow Articles by Miller, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Salmon, A. B.
Right arrow Articles by Miller, R. A.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 63:232-241 (2008)
© 2008 The Gerontological Society of America

Fibroblasts From Naked Mole-Rats Are Resistant to Multiple Forms of Cell Injury, But Sensitive to Peroxide, Ultraviolet Light, and Endoplasmic Reticulum Stress

Adam B. Salmon, Amir A. Sadighi Akha, Rochelle Buffenstein and Richard A. Miller

1 Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor.
2 Department of Pathology and the Geriatrics Center, University of Michigan, Ann Arbor.
3 Department of Biology, City College of New York, New York.
4 The Barshop Institute for Aging and Longevity Studies and 5 Department of Physiology, University of Texas Health Science Center, San Antonio.
6 Ann Arbor VA Medical Center, Michigan.

Address correspondence to Richard A. Miller, MD, PhD, Room 3001 BSRB Box 2200, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200. E-mail: millerr{at}umich.edu

Fibroblasts from long-lived mutant mice are resistant to many forms of lethal injury as well as to the metabolic effects of rotenone and low-glucose medium. Here we evaluated fibroblasts from young adult naked mole-rats (NMR; Heterocephalus glaber), a rodent species in which maximal longevity exceeds 28 years. Compared to mouse cells, NMR cells were resistant to cadmium, methyl methanesulfonate, paraquat, heat, and low-glucose medium, consistent with the idea that cellular resistance to stress may contribute to disease resistance and longevity. Surprisingly, NMR cells were more sensitive than mouse cells to H2O2, ultraviolet (UV) light, and rotenone. NMR cells, like cells from Snell dwarf mice, were more sensitive to tunicamycin and thapsigargin, which interfere with the function of the endoplasmic reticulum (ER stress). The sensitivity of both Snell dwarf and NMR cells to ER stress suggests that alterations in the unfolded protein response might modulate cell survival and aging rate.

Key Words: Longevity • Comparative biology • Naked mole-rat • Stress resistance • Oxidation • Endoplasmic reticulum (ER) stress






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All GSA journals The Gerontologist
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Copyright © 2008 by The Gerontological Society of America.