HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Dayhoff-Brannigan, M. Articles by Semba, R. D. Search for Related Content PubMed PubMed Citation Articles by Dayhoff-Brannigan, M. Articles by Semba, R. D.

Oxidative Protein Damage Is Associated With Elevated Serum Interleukin-6 Levels Among Older Moderately to Severely Disabled Women Living in the Community

¹ Johns Hopkins Medical Institutions, Baltimore, Maryland.
² Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland.
³ Epidemiology, Demography, and Biometry Branch, National Institute on Aging, Bethesda, Maryland.

Address correspondence to Richard Semba, MD, 550 N. Broadway, Suite 700, Baltimore, MD 21205. E-mail: rdsemba{at}jhmi.edu

Background. Elevated interleukin (IL)-6 is associated with adverse outcomes. Our objective was to determine whether serum protein carbonyls, an indicator of oxidative protein damage and oxidative stress, were associated with IL-6.

Methods. Serum protein carbonyls and IL-6 were measured in 739 women, age 65 years, in the Women's Health and Aging Study I.

Results. Geometric mean of protein carbonyls was 0.082 nmol/mg. After adjusting for age and smoking status, log_e serum protein carbonyls were associated with log_e IL-6 (β = 0.143, standard error [SE] = 0.048, p =.003) in linear regression analyses and with elevated IL-6 (2.5 pg/mL) (odds ratio = 1.38, 95% confidence interval, 1.02–1.86, p =.037) in logistic regression analyses.

Conclusion. Oxidative damage to proteins is independently associated with serum IL-6 among older women living in the community. Increased oxidative stress may be a factor involved in the pathogenesis of the proinflammatory state that occurs in older adults.

Key Words: Inflammation • Interleukin-6 • Oxidative stress • Protein carbonyls

This article has been cited by other articles:

				M. H. Noyan-Ashraf, Z. Sadeghinejad, G. F. Davies, A. R. Ross, D. Saucier, T. A. A. Harkness, and B. H. J. Juurlink Phase 2 Protein Inducers in the Diet Promote Healthier Aging J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2008; 63(11): 1168 - 1176. [Abstract] [Full Text] [PDF]