Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Moreno Lima, R.
Right arrow Articles by de Oliveira, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moreno Lima, R.
Right arrow Articles by de Oliveira, R. J.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 62:966-972 (2007)
© 2007 The Gerontological Society of America

Lack of Association Between Vitamin D Receptor Genotypes and Haplotypes With Fat-Free Mass in Postmenopausal Brazilian Women

Ricardo Moreno Lima, Breno Silva de Abreu, Paulo Gentil, Tulio Cesar de Lima Lins, Dário Grattapaglia, Rinaldo Wellerson Pereira and Ricardo Jacó de Oliveira

1 Programa de Pós-Graduação em Educação Física da Universidade Católica de Brasília, Brazil.
2 Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia da Universidade Católica de Brasília, Brazil.

Address correspondence to Ricardo Jacó de Oliveira, PhD, Universidade Católica de Brasília–UCB, Mestrado em Educação Física, QS 07, Lote 01, Prédio São João Bosco, Sala 119. CEP: 71.996-700, Taguatinga–DF–Brazil. E-mail: rjaco{at}ucb.br or rjaco{at}zaz.com.br

The relationship between vitamin D receptor (VDR) ApaI, CDX2, BsmI, FokI, and TaqI polymorphisms and fat-free mass (FFM) were examined in 191 postmenopausal Brazilian women (mean age 67.87 ± 5.22 years). Participants underwent FFM measurements by dual-energy x-ray absorptiometry (DEXA). Whole-blood-extracted genomic DNA was genotyped to the aforementioned polymorphisms and to ancestry-informative markers through minisequencing, using the SNaPshot Multiplex System. Association between VDR polymorphisms and FFM variables was assessed by analysis of covariance. Haplotypes were estimated, and regression-based, haplotype-specific association tests were carried out with the studied phenotypes. No departure from Hardy–Weinberg equilibrium was detected for any polymorphism. None of the investigated VDR allelic variations, individually or analyzed as haplotypes, was associated with FFM phenotypes. The inclusion of individual African genomic ancestry was used as an attempt to correct for population stratification. Further studies in larger sample population are required to confirm these findings.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All GSA journals The Gerontologist
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Copyright © 2007 by The Gerontological Society of America.