Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 62:301-307 (2007)
© 2007 The Gerontological Society of America

REVIEW ARTICLE

Genetic Variation and Human Aging: Progress and Prospects

David Melzer, Alison J. Hurst and Tim Frayling

Peninsula Medical School, University of Exeter, United Kingdom.

Address correspondence to David Melzer, MB, BCh, Peninsula Medical School, RD&E Wonford Site, Barrack Road, Exeter, EX2 5DW, United Kingdom. E-mail: david.melzer{at}pms.ac.uk

The genetics of aging has seen extraordinary progress over the last few decades, with animal models suggesting key roles for a number of metabolic pathways. However, humans outlive laboratory models many times over, and only evidence from humans can ultimately identify the drivers of human aging. In this article we thematically review progress in identifying human genetic variants associated with longevity. We also look at the bigger picture of progress in identifying genetic associates of disease and functioning and healthy aging in older people. Although much of the existing evidence is fragmentary, recent exciting findings and robust methods are taking the field rapidly forward.




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